Anadrol

Vanguard Fitness Oxymetholone 50mg, one of the strongest oral anabolic’s available. Known for explosive strength, rapid size gains, and intense pumps, Anadrol 50mg is for experienced users chasing serious growth.

Anadrol – Harm Reduction Crib Sheet

Compound: Oxymetholone
Class: Oral Anabolic-Androgenic Steroid (AAS), Dihydrotestosterone (DHT) derivative
Administration: Oral

Dosage

• Performance Use: 25–50 mg/day
• Advanced Use: Up to 100 mg/day (not recommended for harm reduction)
• Cycle Length: 2–4 weeks recommended (high liver strain)

Half-Life

• ~8 to 9 hours
• Dosing: Once daily or split into 2 doses (morning/evening)

Benefits

• Rapid and significant increases in size, weight, and strength
• Strong appetite stimulation (in some users)
• No aromatisation – does not convert to oestrogen
• Very effective in short cycles or as a jump-start compound

Side Effects

• Hepatotoxicity: High risk due to 17α-alkylated structure
• Oestrogenic-like effects: Bloating, gynecomastia, water retention (despite no aromatisation)
• Androgenic: Acne, oily skin, hair loss
• Suppression: Severe inhibition of natural testosterone production
• Lipid impact: Profound ↓ HDL, ↑ LDL
• Appetite suppression and lethargy in some users

Risks

• Liver toxicity: Elevated ALT/AST, potential hepatotoxicity, cholestasis
• Cardiovascular strain: Significant due to lipid shifts and water retention
• Hypertension: Common with high doses due to fluid retention
• Endocrine disruption: Profound HPTA suppression
• Reproductive: Infertility and testicular atrophy
• Psychological: Potential mood swings, aggression, fatigue

Risk Mitigation

• Bloodwork: Liver enzymes, lipids, CBC, TT/FT, E2 pre-, mid-, and post-cycle
• Cycle support: TUDCA (250–500 mg/day), NAC, hydration, no alcohol
• Monitor BP: Regular checks due to fluid retention
• Lipid support: Omega-3s, fibre, red yeast rice
• Limit duration: 2–4 weeks only
• Test base: Strongly advised to maintain function and mitigate lethargy

Post-Cycle Therapy (PCT)

If not transitioning to TRT

• Start: 1–2 days after last dose
• Tamoxifen (Nolvadex):
  • 40 mg/day (Weeks 1–2)
  • 20 mg/day (Weeks 3–4)
• Optional – Clomiphene (Clomid): 50 mg/day for 4 weeks
• Follow-up labs: 4–6 weeks post-PCT